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Method for distinguishing “DNA-trapping” and “Non-trapping” PARP inhibitors

Methodology by which to identify candidate PARP inhibitors with strong anti-cancer properties (i.e. “trapping” compounds), as well as PARP inhibitors with low cellular toxicity for treatment of stroke, diabetes, myocardial infarction, neurodegenerative diseases and other diseases (i.e. a “non-trapping” compounds)

Published: 10/30/2023
Inventor(s):
Ben Black
Keywords(s):
 
Category(s):
Technology Classifications > Life Sciences > Research Tools & Reagents, Technology Classifications > Life Sciences > Therapeutics

Method for distinguishing “DNA-trapping” and “Non-trapping” PARP inhibitors

Methodology by which to identify candidate PARP inhibitors with strong anti-cancer properties (i.e. “trapping” compounds), as well as PARP inhibitors with low cellular toxicity for treatment of stroke, diabetes, myocardial infarction, neurodegenerative diseases and other diseases (i.e. a “non-trapping” compounds)

Published: 8/2/2021
Inventor(s):
Ben Black
Keywords(s):
 
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics & Vaccines