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Mutant cytosine modifying enzymes to enhance epigenetic or base-editing on genomic DNA

Mutant TET enzymes that stall the oxidation reaction of 5-methylcytosine (5mC) at 5-hydroxymethylcytosine (5hmC), and AID/APOBEC enzymes with hyperactive deamination activity.

Published: 10/30/2023

Inventor(s):

Rahul Kohli, Christopher Nabel, Emily Schutsky, Monica Yun Liu

Keywords(s):

Category(s):

Technology Classifications > Life Sciences > Research Tools & Reagents, Technology Classifications > Life Sciences > Diagnostics

Mutant cytosine modifying enzymes to enhance epigenetic or base-editing on genomic DNA

Mutant TET enzymes that stall the oxidation reaction of 5-methylcytosine (5mC) at 5-hydroxymethylcytosine (5hmC), and AID/APOBEC enzymes with hyperactive deamination activity.

Published: 8/2/2021

Inventor(s):

Rahul Kohli, Christopher Nabel, Emily Schutsky, Monica Yun Liu

Keywords(s):

Category(s):

Technology Classifications > Research Tools & Reagents, Technology Classifications > Diagnostics