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Method for distinguishing “DNA-trapping” and “Non-trapping” PARP inhibitors

Methodology by which to identify candidate PARP inhibitors with strong anti-cancer properties (i.e. “trapping” compounds), as well as PARP inhibitors with low cellular toxicity for treatment of stroke, diabetes, myocardial infarction, neurodegenerative diseases and other diseases (i.e. a “non-trapping” compounds)

Published: 8/2/2021
Inventor(s):
Ben Black
Keywords(s):
 
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics & Vaccines

Mutant cytosine modifying enzymes to enhance epigenetic or base-editing on genomic DNA

Mutant TET enzymes that stall the oxidation reaction of 5-methylcytosine (5mC) at 5-hydroxymethylcytosine (5hmC), and AID/APOBEC enzymes with hyperactive deamination activity.

Published: 8/2/2021
Inventor(s):
Rahul Kohli, Christopher Nabel, Emily Schutsky, Monica Yun Liu
Keywords(s):
 
Category(s):
Technology Classifications > Research Tools & Reagents, Technology Classifications > Diagnostics

Transcriptome in vivo analysis (TIVA)

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Published: 8/2/2021
Inventor(s):
James Eberwine
Keywords(s):
 
Category(s):
Technology Classifications > Research Tools & Reagents