Search Results - amos+smith

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Novel pyrimidine derivatives to treat Alzheimer’s Disease

Brain penetrating compounds as promising therapeutics for treatment of neurodegenerative disorders.

Published: 10/30/2023
Inventor(s):
Kurt Brunden, Carlo Ballatore, Amos Smith, Virginia Lee, John Trojanowski
Keywords(s):
Aging, Neurodegenerative Diseases, Neurology, Small Molecule
Category(s):
Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Therapeutics

Novel inhibitors of ferroptosis

Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases.

Published: 10/30/2023
Inventor(s):
Robert Wilson, Maria Cotticelli, Shujuan Xia, Donna Huryn, Amos Smith, Taehee Lee, Roberto Forestieri
Keywords(s):
Neurodegenerative Diseases
Category(s):
Technology Classifications > Life Sciences > Therapeutics

Reusable silicon-based cross-coupling agents for the production of natural products, pharmaceuticals, and other organic materials

Cross-coupling reactions without the generation of waste products

Published: 10/30/2023
Inventor(s):
Amos Smith
Keywords(s):
 
Category(s):
Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Physical Sciences > Materials

CD4 mimetic small molecule inhibitors of HIV-1 entry

Therapeutic development for HIV-1 infection and prevention of transmission

Published: 10/30/2023
Inventor(s):
Amos Smith
Keywords(s):
HIV/AIDS, Small Molecule
Category(s):
Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Therapeutics

A novel isostere to replace the carboxylic acid functional group in pharmaceuticals and other compounds

Cycloalkyl-dione derivatives with improved pharmacokinetic and toxicological properties for drug design

Published: 10/30/2023
Inventor(s):
Amos Smith, Donna Huryn, Carlo Ballatore, Virginia Lee, John Trojanowski
Keywords(s):
 
Category(s):
Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Physical Sciences > Materials

An efficient method to produce high yield analogs of Hemi-Phorboxazole A with anticancer and antifungal activities

A two-step, high yield, method for synthesizing naturally derived, Hemi-Phorboxazole A analogs

Published: 10/30/2023
Inventor(s):
Amos Smith
Keywords(s):
 
Category(s):
Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Therapeutics

Phorboxazole compounds as potent anti-tumor agents

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Published: 10/30/2023
Inventor(s):
Amos Smith
Keywords(s):
Oncology
Category(s):
Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Therapeutics