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An ultrasensitive diagnostic tool that isolates single extracellular vesicles (EVs) and measures their contents to single molecule resolution.
A nuclear magnetic resonance (NMR) based enzyme-detection system comprising xenon (129Xe) biosensors complexed with an enzyme-specific peptide substrate.
A method that maintains the viability and function of NK cells following cryopreservation, enabling the production, storage, and transportation of therapeutic doses of NK cells to treatment centers.
A combinatorial library of RGD peptide (arginine-glycine-aspartic acid)-based lipids designed to formulate lipid nanoparticles for targeted mRNA delivery to the liver and the spleen.
A method to expand LNP delivery capabilities to include small scaffold proteins such as nanobodies, DARPins, and Mini proteins.
Thioamide-stabilized peptide specifically inhibiting cathepsin L to block SARS-CoV-2 entry and cancer cell migration
A novel LNP formulation that allows for the conjugation of a chemotherapeutic agent to small interfering RNA (siRNA)-loaded LNP.
Co-expression of modified chimeric antigen receptor (CAR) T cells and cholesterol 25-hydroxylase (CH25H) in a single construct for treatment of solid tumor and hematological cancers.
A platform to isolate and expand CD137-positive (CD137pos) tumor-infiltrating lymphocytes (TILs) to use in adoptive immunotherapy and translational studies.