Search Results - neurology

PennSorter: A software platform for rapid neural signal analysis.

PennSorter is a specialized "spike-sorting" software designed to facilitate the precise assignment of electrical signals to cells with enhanced accuracy and efficiency.

Published: 10/30/2023

Small Molecule Activators of Valosin-Containing Protein (VCP) as Therapeutics for Neurodegenerative Diseases with Ubiquitinated Protein Aggregates

Small molecule therapeutics that aid in clearing abnormal protein deposits observed in neurodegenerative diseases.

Published: 10/30/2023

Inventor(s):

Edward Lee, Benjamin Creekmore, Jessica Phan

Keywords(s):

Aging, Genetic Disorders, Neurodegenerative Diseases, Neurology, Orphan Disease, Small Molecule

Category(s):

Technology Classifications > Life Sciences > Therapeutics

Xenon Biosensors Improve Early Breast Cancer Detection

A nuclear magnetic resonance (NMR) based enzyme-detection system comprising xenon (¹²⁹Xe) biosensors complexed with an enzyme-specific peptide substrate.

Published: 10/30/2023

Inventor(s):

Ivan Dmochowski, Qian Wei, Nicholas Kuzma, Aru Hill

Keywords(s):

Bioengineering, Imaging Agents, Neurology, Oncology, Radiology, Women's Health

Category(s):

Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Imaging

Tunable, Caged Molecules For In Vivo and In Situ Transcriptomic Analyses

Compounds are designed to detect and characterize specific RNAs in a cell or sub-cellular compartment using light activation.

Published: 10/30/2023

Inventor(s):

Ivan Dmochowski, James Eberwine, Sean Yeldell, Julianne Griepenburg, Teresa Rapp, Jennifer Singh, Jai-Yoon Sul, Jae Hee Lee

Keywords(s):

Bioengineering, Neurology, Small Molecule

Category(s):

Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Diagnostics

Design Of Artificial Proteins As Ultrafast, Genetically Encoded Electrophysiological Reporters

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Published: 10/30/2023

Inventor(s):

Brian Chow, Peter Leslie Dutton, Christopher Moser, Bohdana Discher, Nathan Ennist

Keywords(s):

Bioengineering, Neurology, Optics & Photonics , Protein/Peptide (Non-Antibody)

Category(s):

Technology Classifications > Physical Sciences > Testing & Measurement, Technology Classifications > Life Sciences > Research Tools & Reagents, Technology Classifications > Physical Sciences > Business Ideas

Naturally flexible, adhesive, and conductive hydrogel electrodes for medical sensing

A hydrogel that combines conductive additives with the strength of dynamic bonds to create a naturally flexible and adhesive electrode.

Published: 10/30/2023

Inventor(s):

Flavia Vitale, Shu Yang, Mehrnaz Mojtabavi, Brendan Murphy, Mingtao Chen, Baohong Chen, Yuchong Gao

Keywords(s):

Bioengineering, Cardiovascular, Hydrogels, Neurology, Soft Materials

Category(s):

Technology Classifications > Physical Sciences > Materials, Technology Classifications > Life Sciences > Medical Devices

Effective and pain-reducing foot device to treat pain and loss of feeling from diabetic neuropathy

Implantable foot device to restore feeling and reduce pain associated with diabetic nerve complications.

Published: 10/30/2023

Inventor(s):

Timothy Lucas, Andrew Richardson, Firooz Aflatouni, Mark Allen

Keywords(s):

Neurology, Obesity, Metabolic Disease and Diabetes

Category(s):

Technology Classifications > Life Sciences > Medical Devices, Technology Classifications > Life Sciences > Therapeutics

Therapeutic to mitigate epilepsy and autism development in newborn seizure patients

Neonatal brains are at high risk for seizures due to heightened electrical activity corresponding to neural development. Though anticonvulsant drugs exist to treat the seizures immediately, certain synaptic receptors (CP-AMPARs) become highly expressed, increasing the likelihood of developing epilepsy and autism-spectrum disorders. The inventors propose using CP-AMPAR blockers such as IEM-1460 to curb CP-AMPAR activity and prevent development of epilepsy and other neurological disorders.