Search Results - ivan+dmochowski

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Xenon Biosensors Improve Early Breast Cancer Detection

A nuclear magnetic resonance (NMR) based enzyme-detection system comprising xenon (129Xe) biosensors complexed with an enzyme-specific peptide substrate.

Published: 10/30/2023
Inventor(s):
Ivan Dmochowski, Qian Wei, Nicholas Kuzma, Aru Hill
Keywords(s):
Bioengineering, Imaging Agents, Neurology, Oncology, Radiology, Women's Health
Category(s):
Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Imaging

Tunable, Caged Molecules For In Vivo and In Situ Transcriptomic Analyses

Compounds are designed to detect and characterize specific RNAs in a cell or sub-cellular compartment using light activation.

Published: 10/30/2023
Inventor(s):
Ivan Dmochowski, James Eberwine, Sean Yeldell, Julianne Griepenburg, Teresa Rapp, Jennifer Singh, Jai-Yoon Sul, Jae Hee Lee
Keywords(s):
Bioengineering, Neurology, Small Molecule
Category(s):
Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Diagnostics

Ruthenium photolinkers for manipulating molecular structure and function in materials science and biology

New paradigm for caging and photoreleasing polymeric systems with visible light responsive ruthenium photolinkers.

Published: 10/30/2023
Inventor(s):
Ivan Dmochowski
Keywords(s):
 
Category(s):
Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Imaging, Technology Classifications > Physical Sciences > Materials, Technology Classifications > Life Sciences > Research Tools & Reagents

Tri-functionalized cryptophane biosensors for biomolecular imaging and MRI diagnostics

Cryptophanes with high xenon affinity enable ultrasensitive detection of analytes in solution using Xe-129 NMR/MRI

Published: 10/30/2023
Inventor(s):
Ivan Dmochowski
Keywords(s):
 
Category(s):
Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Imaging

A genetically encoded β-lactamase reporter for ultrasensitive 129Xe NMR and MRI in mammalian cells

Hyperpolarized xenon chemical exchange saturation transfer (CEST) contrast agent for molecular imaging

Published: 10/30/2023
Inventor(s):
Ivan Dmochowski
Keywords(s):
Imaging Agents, Radiology
Category(s):
Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Imaging, Technology Classifications > Life Sciences > Research Tools & Reagents

Photo-modulation of gene expression and RNA hydrolysis through photoactivatable oligonucleotide constructs

Light-activated DNA hairpin to control RNA digestion in gene silencing with mRNA-antisense complexes

Published: 10/30/2023
Inventor(s):
Ivan Dmochowski
Keywords(s):
 
Category(s):
Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Research Tools & Reagents

Photolinker to cage biological molecules

Turn Genes “On” or “Off” with Light

Published: 8/2/2021
Inventor(s):
Ivan Dmochowski
Keywords(s):
Gene Therapy
Category(s):
Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials