Search Results - gene+therapy

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mRNA Therapeutics for Corneal Endothelium Regeneration

A novel mRNA-based therapy that induces corneal endothelium regeneration to restore vision loss

Published: 10/30/2023
Inventor(s):
Panteleimon Rompolas
Keywords(s):
Gene Therapy, Healthcare IT, Ophthalmology
Category(s):
Technology Classifications > Life Sciences > Therapeutics

Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery

Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells.

Published: 10/30/2023
Inventor(s):
Michael Mitchell, Margaret Billingsley, Savan Patel, Xuexiang Han, Hanwen Zhang
Keywords(s):
Bioengineering, Cell Therapy, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Immunotherapy, Inflammation, Nanotechnology, Platform Technology
Category(s):
Technology Classifications > Life Sciences > Therapeutics

Ionizable Lipid Nanoparticles For In Vivo mRNA Delivery To The Placenta During Pregnancy

Lipid nanoparticles for selective mRNA delivery to the placenta to treat pre-eclampsia, FGR, and other pregnancy-related disorders.

Published: 10/30/2023
Inventor(s):
Michael Mitchell, Kelsey Swingle
Keywords(s):
Bioengineering, Drug Delivery, Gene Therapy, Platform Technology, Women's Health
Category(s):
Technology Classifications > Life Sciences > Therapeutics

Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis

A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver.

Published: 10/30/2023
Inventor(s):
Michael Mitchell, Xuexiang Han
Keywords(s):
Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Platform Technology, Regenerative Medicine
Category(s):
Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Vaccines

Amniotic Fluid Stabilized Lipid Nanoparticles (LNPs) for In Utero Intra-Amniotic mRNA Delivery

Nanoparticles for potent encapsulation and delivery of therapeutic molecules for prenatal fetal therapy in the amniotic sac

Published: 10/30/2023
Inventor(s):
Michael Mitchell, Kelsey Swingle, Margaret Billingsley, William Peranteau
Keywords(s):
Bioengineering, Cell Therapy, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Nanotechnology, Orphan Disease, Platform Technology
Category(s):
Technology Classifications > Life Sciences > Therapeutics

Versatile virtual reality system for functional vision evaluation

Virtual reality-based system and software for quick, accurate, and reproducible evaluation of functional vision capacity following clinical treatment

Published: 10/30/2023
Inventor(s):
Jean Bennett, Tomas Aleman, Manzar Ashtari, Alexander Miller, Albert Maguire, Nancy Bennett
Keywords(s):
Augmented Reality (AR) & Virtual Reality (VR), Gene Therapy, Genetic Disorders, Ophthalmology
Category(s):
Technology Classifications > Life Sciences > Diagnostics

Efficient and controllable genome editing complex

A split enzyme complex enabling precise gene editing

Published: 10/30/2023
Inventor(s):
Rahul Kohli, Kiara Berrios, Junwei Shi
Keywords(s):
Cell Therapy, Gene Editing, Gene Therapy
Category(s):
Technology Classifications > Life Sciences > Research Tools & Reagents, Technology Classifications > Life Sciences > Therapeutics

High performance CRISPR-Cas12a system for combinatorial genetic manipulation

CRISPR-Cas12a allowing for simultaneous editing of multiple genes in mammalian cells

Published: 10/30/2023
Inventor(s):
Junwei Shi, Rodrigo Gier
Keywords(s):
Cell Therapy, Gene Therapy, Immunoncology
Category(s):
Technology Classifications > Life Sciences > Research Tools & Reagents

Gene therapy for treatment of Duchenne Muscular Dystrophy (DMD)

Duchenne Muscular Dystrophy (DMD) therapy deletes let-7c miRNA binding sites using CRISPR-Cas9 based genome editing and AAV based delivery.

Published: 10/30/2023
Inventor(s):
Tejvir Khurana
Keywords(s):
Gene Therapy
Category(s):
Technology Classifications > Life Sciences > Therapeutics

Gene Therapy for Macular Degeneration

Gene therapy targeting disposal of toxic intracellular lipid debris and lipofuscin in wet age related macular degeneration.

Published: 10/30/2023
Inventor(s):
Kathleen Boesze-Battaglia
Keywords(s):
Gene Therapy, Ophthalmology
Category(s):
Technology Classifications > Life Sciences > Therapeutics
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