Search Results - xuexiang+han

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Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery

Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells.

Published: 10/30/2023
Inventor(s):
Michael Mitchell, Margaret Billingsley, Savan Patel, Xuexiang Han, Hanwen Zhang
Keywords(s):
Bioengineering, Cell Therapy, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Immunotherapy, Inflammation, Nanotechnology, Platform Technology
Category(s):
Technology Classifications > Life Sciences > Therapeutics

Doxorubicin-Conjugated siRNA Lipid Nanoparticles (LNPs) for Combination Cancer Therapy

A novel LNP formulation that allows for the conjugation of a chemotherapeutic agent to small interfering RNA (siRNA)-loaded LNP.

Published: 10/30/2023
Inventor(s):
Michael Mitchell, Kamila Butowska, Xuexiang Han
Keywords(s):
Bioengineering, Drug Delivery, Immunoncology, Oncology, Platform Technology, Small Molecule
Category(s):
Technology Classifications > Life Sciences > Research Tools & Reagents, Technology Classifications > Life Sciences > Therapeutics

Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis

A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver.

Published: 10/30/2023
Inventor(s):
Michael Mitchell, Xuexiang Han
Keywords(s):
Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Platform Technology, Regenerative Medicine
Category(s):
Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Vaccines