A method that maintains the viability and function of NK cells following cryopreservation, enabling the production, storage, and transportation of therapeutic doses of NK cells to treatment centers.
Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells.
Thioamide-stabilized peptide specifically inhibiting cathepsin L to block SARS-CoV-2 entry and cancer cell migration
A novel LNP formulation that allows for the conjugation of a chemotherapeutic agent to small interfering RNA (siRNA)-loaded LNP.
Co-expression of modified chimeric antigen receptor (CAR) T cells and cholesterol 25-hydroxylase (CH25H) in a single construct for treatment of solid tumor and hematological cancers.
A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver.
A platform to isolate and expand CD137-positive (CD137pos) tumor-infiltrating lymphocytes (TILs) to use in adoptive immunotherapy and translational studies.
A platform technology utilizing synthetic organelles to modulate cell cycle, cell behavior, and stemness/differentiation status which could be used for cell engineering, cell therapy etc.
A dietary supplement that protects brain cells from the effects of TBI and concussion
A method to rapidly detect the presence of EGFRvIII mutations in cancers and normal tissue using digital PCR.