Search Results - drug+delivery

RGD Peptide-Based Lipids For Targeted mRNA Delivery and Gene Editing Applications

A combinatorial library of RGD peptide (arginine-glycine-aspartic acid)-based lipids designed to formulate lipid nanoparticles for targeted mRNA delivery to the liver and the spleen.

Published: 10/30/2023

Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery

Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells.

Published: 10/30/2023

Inventor(s):

Michael Mitchell, Margaret Billingsley, Savan Patel, Xuexiang Han, Hanwen Zhang

Keywords(s):

Bioengineering, Cell Therapy, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Immunotherapy, Inflammation, Nanotechnology, Platform Technology

Category(s):

Technology Classifications > Life Sciences > Therapeutics

A Lipid Nanoparticle (LNP) Platform for Intracellular Protein Delivery of RAS Inhibitors for In Vivo Cancer Therapy

A method to expand LNP delivery capabilities to include small scaffold proteins such as nanobodies, DARPins, and Mini proteins.

Published: 10/30/2023

Inventor(s):

Michael Mitchell, Andrew Tsourkas, Alexander Chan, Rebecca Haley

Keywords(s):

Drug Delivery, Nanotechnology, Oncology, Protein/Peptide (Non-Antibody)

Category(s):

Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Life Sciences > Therapeutics

Ionizable Lipid Nanoparticles For In Vivo mRNA Delivery To The Placenta During Pregnancy

Lipid nanoparticles for selective mRNA delivery to the placenta to treat pre-eclampsia, FGR, and other pregnancy-related disorders.

Published: 10/30/2023

Inventor(s):

Michael Mitchell, Kelsey Swingle

Keywords(s):

Bioengineering, Drug Delivery, Gene Therapy, Platform Technology, Women's Health

Category(s):

Technology Classifications > Life Sciences > Therapeutics

Doxorubicin-Conjugated siRNA Lipid Nanoparticles (LNPs) for Combination Cancer Therapy

A novel LNP formulation that allows for the conjugation of a chemotherapeutic agent to small interfering RNA (siRNA)-loaded LNP.

Published: 10/30/2023

Inventor(s):

Michael Mitchell, Kamila Butowska, Xuexiang Han

Keywords(s):

Bioengineering, Drug Delivery, Immunoncology, Oncology, Platform Technology, Small Molecule

Category(s):

Technology Classifications > Life Sciences > Research Tools & Reagents, Technology Classifications > Life Sciences > Therapeutics

Modified Lipid Nanoparticle Formulations with Improved Therapeutic Delivery to the Bone Microenvironment In-vivo

A library of bi-phosphonate ionizable lipids and LNP formulations to facilitate mRNA delivery to the bone microenvironment.

Published: 10/30/2023

Inventor(s):

Michael Mitchell, Lulu Xue

Keywords(s):

Drug Delivery, Drug Target, Nanotechnology, Orthopedics, Platform Technology, Regenerative Medicine

Category(s):

Technology Classifications > Life Sciences > Vaccines, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Research Tools & Reagents

Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis

A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver.

Published: 10/30/2023

Inventor(s):

Michael Mitchell, Xuexiang Han

Keywords(s):

Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Platform Technology, Regenerative Medicine

Category(s):

Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Vaccines

Precise hydrophobic patterning of microfluidic channels for high throughput production of multi-order emulsions.

Method to micropattern the channels in a Very Large Scale Microfluidic Integrated (VLSMI) chip for high throughput multi-order emulsion production.

Published: 10/30/2023

Inventor(s):

Daeyeon Lee, Jingyu Wu, David Issadore, Sagar Yadavali

Keywords(s):

Drug Delivery, Microfluidics, Small Molecule, Soft Materials

Category(s):

Technology Classifications > Physical Sciences > Chemical Processes and Synthesis, Technology Classifications > Physical Sciences > Materials

Novel nanoparticle composition targeting marginated leukocytes

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Published: 10/30/2023

Inventor(s):

Jacob Myerson, Jacob Brenner, Vladimir Muzykantov, Landis Walsh, Priyal Patel

Keywords(s):

COVID-19, Drug Delivery, Infectious Disease, Inflammation, Nanotechnology, Pulmonary

Category(s):

Technology Classifications > Life Sciences > Therapeutics

Microfluidic device for large-scale production of lipid nanoparticles

A scalable, parallelized, multi-channel microfluidic device for generating lipid nanoparticles.

Published: 10/30/2023

Inventor(s):

Michael Mitchell, David Issadore, Sarah Shepherd, Sagar Yadavali

Keywords(s):

Bioengineering, Drug Delivery, Microfluidics, Nanotechnology

Category(s):

Technology Classifications > Physical Sciences > Materials, Technology Classifications > Life Sciences > Therapeutics

Search Results - drug+delivery

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